Many critics assumed this song is about Tameka Foster, but Usher told The Boombox
that is not the case. "The other day I heard something, someone had assumed that 'What Happened to U' was about my previous relationship with Tameka," he said. "It is not at all."Instead it turns out to be "more of an introspective look" at Usher's initial venture into the music industry and how he cut off a romantic relationship early on in his career. "It's all about the sacrifices we have to make as entertainers," he explained, "and the fact that when I first signed as an artist, I had a decision to make and I feel like the relationship with my first girlfriend, suffered in that way."