This was originally released on Whitesnake's 1980 album Ready an' Willing where it was a #13 hit on the British charts in 1980 and reached #53 in the US. The band re-recorded the track on their 1989 studio album Slip Of The Tongue, and it became a hit single again, reaching a high of #43 in the UK and #37 in the US.
Co-written by David Coverdale, Bernie Marsden and Micky Moody, the song was inspired by the breakup of Coverdale's first marriage. In Firecracker magazine, Coverdale said: "You can look at my first marriage and see 'Fool For Your Lovin' and 'Don't Break my Heart Again.' A lot of those were fueled by songs about a relationship that once was very positive but sadly was unfolding into not positive."
According to Coverdale, the song was written for B.B. King, which is why the original version has a bluesy feel.
Glenn Hughes, who was Coverdale's bandmate for a time in Deep Purple, contributed vocals to the 1989 version of the song.