Frontman Stephen Christian explained this song's lyrical content to Billboard magazine: "I'm so intrigued by conspiracy theories. I'm not a believer in them but I read them methodically because I think they're this cusp of reality that I can't grasp, that I can't relate to, and so it was kind of like the lyrics of the song were about conspiracy theorists and those who buy into Obama as the anti-christ. [It feels like those people] are slaves to this alternate thinking, and it's bound to destroy them. It's just bound to negate anything they've ever said as truth, and so that's what the song's about."
When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.