The central theme of the song is about the tension between the temptations of selling your soul to the Devil to gain fame and riches and trying to maintain a clean soul. A$AP Rocky is open about his use of illegal drugs such as LSD and sleeping around with women, but he still maintains a relationship with God. He said during an interview with Sway in the Morning: "I pray everyday to God. I pray over cookies before I eat 'em. I'm thankful for blessings, and I talk to God everyday."
London newcomer Joe Fox croons the hook over Danger Mouse's psychedelic production. He recalled to Fader: "I had that 'Holy Ghost, I'm on my knees hook.' Rocky wrote the entire rap for that in one night. He just put it down. I think if things are meant to happen, then they just happen quite quickly and organically. It was never a struggle."
"Sloop John B" is a traditional West Indian folk song, and it was a huge hit for The Beach Boys in 1966. They tweaked the lyric, "This is the worst trip since I've been born" to "...I've ever been on" as a wink to acid culture.
"Kickstart My Heart" is about all the ways Motley Crue gets their blood flowing without drugs. It was inspired by their bass player Nikki Sixx, who claimed he had to be revived with a shot of adrenaline to the heart after an overdose.