This was the first new song to be released by Faith Mo More, since the band originally disbanded in 1998. Keyboardist Roddy Bottum said, "It feels apt that the first track we're releasing is 'Motherf--ker,' a song about accountability. Basically we've created, recorded and mixed a new body of work by ourselves and we're releasing it on our own label. It's a huge deal for us to only have ourselves to answer to at this point in our career and the song is about that, where the buck stops via the basic imagery of foie gras production, bondage... y'know, stuff like that."
The song was first played on a concert in July 2014's British Summer Time Hyde Park concert, along with another new Faith No More tune titled called "Superhero."
A seven-inch single containing the song was released on Record Store Day's Black Friday, November 28, 2014 with a limited print of 5,000 copies.