The song's lyrical content came from a deeply personal place. Hellyeah frontman Chad Gray
explained to Noisecreep
: "There's such a low regard I think for human existence and human life. I had a rider friend who was murdered and you know, I saw all my circle of friends, the family and so many people are affected by that. We've all experienced the loss of time, and 'Blood for Blood' is just that."