Regions Of Light And Sound Of God was inspired by Lynd Ward's 1929 graphic novel God's Man, which tells of a struggling artist who sells his soul to the devil in order to get a magic paintbrush that allows him to instantly become famous. James explained to Spin magazine that he wrote this song "for when the guy is progressing in the city."
Speaking with Billboard magazine, James said the song "started as just a sound collage." He explained: "I've been into getting into trances in general and meditating. I'm really into Fela Kuti and James Brown and music that's super repetitive, like the same [riff] for fu--ing 10 minutes while all this other s--t's changing on top of it. That one started with this loop that went on for much longer than is on the record. That's often how things like that'll start; I'll just play that thing for 10 minutes and then solo all over it and then pick out the parts I like and condense it to the best parts. I tried to make the beginning and end of the body of 'Know Till Now' a sound collage of different parts floating through space and I just felt like that ending thing came out of nowhere like a big ship or something."