Layla from Charleston, ScIt seems to speak of Caleb Followill's alcohol issues. IMHO, Caleb's "Amigo" is alcohol or more precisely, his addiction. For anyone who has ever loved an alcoholic, the identity of that friend is all too familiar.
Robert from Fall River, WiEnter your comment here...I think this song is about a good friend that gets drunk with him.
Cameron from Cyclone, WvActually he says: "Walks my ass home".