This song finds Madonna pleading for a sign from God over an acoustic guitar. There are also a number of references to illegal substances. The singer explained to David Blaine during a chat for Interview Magazine, that the track was inspired by people's misguided use of drugs to connect with a higher being. "It's about how people take drugs to connect to God or to a higher level of consciousness," Madonna said. "I keep saying, 'Plugging into the matrix'. If you get high, you can do that, which is why a lot of people drop acid or do drugs, because they want to get closer to God."
"But there's going to be a short circuit, and that's the illusion of drugs, because they give you the illusion of getting closer to God, but ultimately they kill you. They destroy you," she continued. "I mean, I tried everything once, but as soon as I was high, I spent my time drinking tons of water to get it out of my system. As soon as I was high, I was obsessed with flushing it out of me. I was like, 'OK, I'm done now.'"