Six days after Henry IV of France's marriage to the Protestant Marguerite de Valois in August 1572, the Saint Bartholomew's Day Massacre kicked off in Paris. Over three thousand Huguenots who had come to the French capital for Henry's wedding were killed, as well as thousands more throughout the country in the days that followed.
In the years following the Saint Bartholomew's Day Massacre, hundreds of thousands of Huguenots fled France and sought safety in other countries of northern Europe. An estimated 50,000 of crossed the English Channel to England, and it was then that the word 'refugee' first entered the English language. (Source The Encyclopedia of Trivia