The Allman Brothers, who often did their own interpretation of blues songs, recorded a popular version of this song for their 1969 debut album. It was one of 22 songs Gregg Allman brought to the band when he joined, and it was the first song they played together for an audience. That performance was on song was on May 11, 1969 when they played at Piedmont Park in Atlanta at a free festival sponsored by an underground newspaper; the paper gave them a glowing review and put them on the map outside of Macon.
The song became a live favorite for the band; a version from a show at The Fillmore East appears on the Allman Brothers album Eat A Peach, which was released after Duane Allman died in a motorcycle accident.
On October 28, 2014, the band played their final show, a farewell concert at the Beacon Theater in New York City. Their final song was "Trouble No More."