Songfacts®:

• Muse's seventh album Drones opens with this funky rocker where Matt Bellamy sings about the tumultuous end of a relationship. The song sets up the record's concept concerning the journey of a person who has lost all hope. After being indoctrinated by the system into becoming a human drone, he eventually defects away from this oppressors.
  
  Matt Bellamy explained: "This is where the story of the album begins, where the protagonist loses hope and becomes 'Dead Inside', therefore vulnerable to the dark forces introduced in 'Psycho' and which ensue over the next few songs on the album, before eventually defecting, revolting and overcoming these dark forces later in the story."
• Muse performed the song live for the first time during a gig in Brighton on England's south coast on March 23, 2015.
• Matt Bellamy separated from his wife, actress Kate Hudson, in 2014 and this song reflects his feelings about their split. He told Q magazine that "Dead Inside" was about, "a relationship ending and a person becoming dead inside themselves."
• The song's music video was directed by Robert Hales, who has a MTV Video Music Award on his sideboard for shooting the clip for Gnarls Barkley's "Crazy."
  
  The visual features American contemporary dancer Kathryn McCormick and So You Think You Can Dance finalist Will Wingfield moving in time to the music being performed by the band. Their scenes were choreographed by Tessandra Chavez, the CEO of Unity Dance Ensemble, who is known for her work on the aforementioned So You Think You Can Dance.