The song's music video features Scorpio (aka Nikki Diamond) from TV's Gladiators and the Australian actor Guy Pearce (L.A. Confidential, Iron Man 3) as the blue superhero. Razorlight frontman Johnny Borrell recalled to NME of the latter: "He's such a good actor that he just pulled it off – we got Guy Pearce in the video and nobody recognised him! He's this old Superman and he looks too convincing with his rotten teeth. No one knew it was Guy Pearce."
"Kickstart My Heart" is about all the ways Motley Crue gets their blood flowing without drugs. It was inspired by their bass player Nikki Sixx, who claimed he had to be revived with a shot of adrenaline to the heart after an overdose.