The appearance by the Tower of Power horn section marked the first time Santana used guest musicians. It was also just the second time Tower of Power farmed out their horns (the first being "Funkie Jim" by Big Brother And The Holding Company) - something they would do often over the next 50 years.
"I think the rhythmic horns on the verses really made the song bounce, since Santana was such a rhythmic band," ToP leader Emilio Castillo told Songfacts
. "You can tell how excited Santana was by how loud the horns are in the mix. Carlos had called us in the middle of the night saying, 'We recorded this song and we think it would sound good with your horns on it. Would you guys come over to the studio?'
We were all hanging out partying and thought that would be a lot of fun, so we drove right over and quickly made up some parts. It was mixed and released within one week and everyone was marveling that Santana had these cool horns on his new single. All the DJs were saying, 'That's Santana's new single with Tower of Power horns!'
The sessions started rolling in after that. We did a lot of recording with Santana over the next few years and played live with him as well, but 'Everybody's Everything' is the song people always remember about our collaborations with Carlos."