Songfacts®:

• Chainsmokers singer Andrew Taggart croons on this song about the downside of fame and how it isn't all it's cracked up to be:
  
  Yeah, things were sweet three months ago
  When I was living how I wanna on my own
  And I thought I-I-I-I-I-I don't need that much
  I guess I-I-I-I-I-I was out of touch
  
  Chainsmokers explained: "In the year that we spent writing this album, a lot changed. We experienced fame for the first time. It wasn't what we expected. After years of being relatively unknown, all of a sudden people were commenting on everything we did from what we wore to what we tweeted. The feeling of being taken out of context and misrepresented in the media weighed heavily on us. While the song represents the frustration in dealing with our newfound attention it also touches on relationship."
  
  "We are often criticized for being 'party boys' in what seems to be an attempt to discredit our artistry, when in fact, our partying has led to some of our most sobering song writing moments," they added. "We wrote this song at 4am in London after one of our shows at Brixton. Bloodstream is about the acceptance of who we are from ourselves."
• The title doesn't appear in the lyrics, but seems to be a reference to alcohol in the bloodstream. (The song's first line is "I've been drunk three times this week.")
• New Jersey born and LA-based singer-songwriter Phoebe Ryan contributes backing vocals on the chorus. She featured on The Chainsmokers' 2016 hit single "All We Know."
• Ed Sheeran also has a song in his resume with the same title. He wrote his "Bloodstream" tune about an experience taking ecstasy in Ibiza. Released as a single it peaked at #2 in the UK in 2014.