Singer Rob Harvey told The Sun June 13, 2008 about this song: "This is not an anti-drugs or pro-drugs song. It's more of an acceptance that we need to handle drugs in a more sensitive way. From education at schools to addiction as adults, it scares me how much they can affect us as individuals and as a country. It's also about the hypocrisy surrounding drugs in society."
"Here Comes Your Man" is the closest the Pixies came to a hit in America. It was rumored to be about a drug dealer, but Black Francis says it's just a story about some hobos who travel by train and die in an earthquake.