Frontman Alan Donohoe told the Independent newspaper May 9, 2008 about the background to this song: "I still had my office job for the NHS at the Royal Free Hospital and I'd used all my year's holiday to go on tour with the band. It was very stressful - heavy partying and coming back to heavy jobs - and that song was my transition from humble NHS office worker into fully fledged rock'n'roll star. It summed up the, albeit temporary, mild depression of a stressful, busy month."
Two tears roll down Sinead O'Connor's face. toward the end of the video for "Nothing Compares 2 U." They were shed because she associated the song's lyrics of love and loss with her mother, who was killed in a car accident in 1985.