The titling of the Dear Science album was triggered by news of the switching on of the world's largest particle accelerator along the French-Swiss border. The collider is an attempt to study the big-bang theory by re-creating the big bang. However many have feared that if the particle accelerator succeeds, it will create a black hole, which will swallow the Earth, wiping out everything. Vocalist Tunde Adebimpe explained to Rolling Stone that this news provoked guitarist Dave Sitek to write a letter. Said Ademimpe: "Dave (Sitek) had written this letter addressed to science in kind of a kid's handwriting and it said, 'Dear Science, please fix all the things you keep talking about or shut up.' And that ended up in the washer when we were picking titles. I think we're going to post all of the titles, because while we were recording the record, everyone would give their two cents as to what the title should be. There's a long, long list of horrible titles. Dear Science is probably the most tasteful of all of those."
Sitek wrote his letter on a yellow legal pad and pinned it to the wall of the band's Brooklyn recording studio. It subsequently served as the liner notes to the Dear Science album.