In this song 50 Cent recounts some of his adventures when he was in an intoxicated state, during his younger days.
50 Cent pilfered the song's beat from Dr. Dre's studio sessions with Eminem. He explained to MTV News: "I did a song produced by Dr. Dre. I got the production from Detroit, because Dre was working with Em right before I got out there. I just missed him. I went through Em's computer and found what I needed. Yes, I did. I got me the record I needed. I was like, 'Wait till they hear this.' I wrote it; Em heard it. He was like, 'You gotta keep that for yourself. This is too crazy.' First, I think he was gonna take it from me, then he was like, 'He gotta use that for himself.'"
Mike Campbell from Tom Petty & the Heartbreakers played the slide guitar on "Sixth Avenue Heartache." There is a connection here - Wallflowers lead singer Jakob's dad, Bob Dylan, played with Tom Petty in The Traveling Wilburys.