This song finds Game spitting verses about various women ranging from Kanye West's mother to Notorious B.I.G.'s daughter. It is dedicated to teenager Natalee Holloway, who disappeared in 2005, after vacationing on the Caribbean island of Aruba. "We don't want to see Nicki fightin' Lil' Kim/ There's missing women out there, let's focus on them," the Compton Rhymer raps.
The song was produced by Cool & Dre and features Canadian rapper Drake, whose rhymes center more on the physical aspects of ladies.
Game explained the Natalee Holloway dedication to The Boombox: "I say a line in the beginning paying homage to her father and his feelings. When I saw him on CNN one night, it had actually happened to be Father's Day, so I just started the song off like that. Specifically because that's a situation that sort of rendered that family helpless. I got a daughter and, at that time my daughter wasn't born, but if anything like that ever happened I would never come back to sanity."
New York City rappers Lil' Kim and Nicki Minaj have had a longstanding beef, which arose when Kim publicly accused Minaj of copying her style. This track includes some lines where Game urges the two female MCs to cease their hostilities. He explained to The Boombox: "Because I think that Lil' Kim was golden in her time and I think that Nicki Minaj is the re-birth of Kim and I don't think they should be fighting. Kim is a legend and should be respected and Nicki is dope as f--- and she's going to end up being the best female rap vocalist ever. I thought it [the beef] was just nonsense."
Game explained to Billboard magazine how the song is partly the story of his mom and dad: "My dad is eleven years older than my mom and he just beat my mom this way and that way my entire childhood. Then one day my mom ran him over with a car and almost paralyzed him. [She] pinned him between a 87 Regal and a steel rod fence. That song is real in life. I started off telling stories that were real, sentimental and that people would feel and Drake came in and made it real fun. So on my third verse I went back and traced that and made it fun. Produced again by Cool & Dre."