If you read a drug connection into this song, you're on the right track. Donald Fagen
describes it as "kind of a love-dope triangle," adding, "I think usually when we do songs of a romantic nature, one or more of the participants in the alliance will come under the influence of someone else or some other way of life, and that will usually end up in either some sort of compromise or a split. In this song the girl meets somebody who leads another kind of life, and she's attracted to it. Then she comes under the domination of someone else, and that results in the ending of the relationship or some amending of the relationship. In 'Dr. Wu' that someone else is a dope habit. personified as Doctor Wu."