The song initially lasted four weeks in the UK top 100 following its 2004 re-release, but has since become a staple of wedding parties and student discos, frequently re-entering the UK singles chart.
On April 1, 2021, The Official Charts Company announced that "Mr Brightside" had spent 260 non-consecutive weeks – or five full years – in the top 100 of the UK singles chart since its re-release in 2004. No other song has notched up anywhere near as many weeks. The second-longest-running chart hit at the same date was Snow Patrol's "Chasing Cars
," with a total of 166 weeks in the tally.