This is the title track from California rock band Train's fifth studio album. It was their first release for nearly four years. Lead guitarist Jimmy Stafford told Billboard magazine that he considers Save Me San Francisco, "a comeback record... It's kind of like we're re-introducing the band to everybody. We have to go out there and win back our core fans and also expand our audience with new fans." He added: "We just wanted to get back to our roots on this record. We wanted to do things a little more stripped-down like our first album and get back to the whole San Francisco vibe, which is were the band originally came from. And it's working out great. We've got the same energy and excitement that we had on the first album. Everybody's just on the same page and really excited."
Stafford told The Huffington Post: "When I heard Pat's demo of 'Save Me, San Francisco,' I really got goose bumps, I felt like it was a really impressive hit song. I love the chorus so much, you know, with that gospel singer vibe. It had a Stones attitude, like a loose kind of f--- off rock song. Lyrically, it's a good pop song, but as a whole, it has a good groove and is really fun to play."