While the band was recording the music for this song, David Lee Roth recorded comments ("I like the way the line runs up the back of your stocking," etc.) onto a separate track. They were then mixed in with the song. At the end, Roth says, "Sure, I'll pay you for it, what the f--k." The obscenity fades just enough that most radio stations don't worry about editing it out.
Eddie Van Halen played the solo for this with both hands on the freeboard of his guitar. At concerts, he used a board to support the guitar and free up his hands so he could play it.
For the first line in the second verse, Roth meant to sing "I've seen a lot of people just looking for a moonbeam," but forgot the words when he was recording it and just slurred out some gibberish that came close. They liked the attitude in the vocal, so they kept it anyway. The resulting lyric became the topic of wide speculation, but it couldn't be misheard because it was misspoken to begin with.
The song is performed by a claymation hamburger playing an Eddie Van Halen-inspired guitar in the John Cusack movie Better Off Dead.
Richard Linklater's 2016 film Everybody Wants Some!! takes its title from this song.