In Gary Numan's "Cars," the message is that cars lead to a mechanical society devoid of personal interaction. This didn't stop automakers from using it in commercials. Both Nissan and Oldsmobile have used it in ads.
"The Way" by Fastball was inspired by the story of an elderly couple from Texas who drove to a nearby family reunion and kept going. Fastball's bass player imagined them taking off and having fun like they were young. The story didn't end well: the couple was later found dead after they crashed in a canyon.