This is the first single from Jeezy's fourth studio album, Thug Motivation 103. The track features Florida rapper Plies and was debuted by Jeezy in a live performance on February 27th 2010 at the Philips Arena in Atlanta.
Jeezy described this track to MTV News as a quick snapshot of his nightlife. "To me, it's my life," he said. "That's how I feel sometimes when I go out. If you listen to me, I said it a few times: 'Lost my mind and my cell phone in the same night.' No two days are the same. I been partying my whole life. That's how you feel the next day. You killed them, and you left. You was looking good, shining good, there's no limit to what you can have in the club. That's how it's been for us before music. 'Lose My Mind' is doing what the hell I wanna do in the club. If it's 100 bottles of rosé, if it's 40 bottles of Belvedere, if it's all the kush in the world. I'mma do what I wanna do. When I leave there, I don't wanna remember nothing. I just wanna wake up and do the same thing again. That's what 'Lose Your Mind' is about. You gotta have life your way. If you ain't losing your mind, you ain't partying right."
Jeezy told MTV News how he hooked up with Plies: "To keep it all the way 100 with you, we did a record called 'So Sad,' " he explained. "Before I could put it out, the record leaked, so we was good on that. Then I was gonna do a record for him [for his album]. I did the record, by the way, but I had 'Lose My Mind.' I done three verses. I listened to it a couple of times. I said, 'Let me try something. I'mma put somebody on the record.' I was doing a joint for him at the time and happened to see him. We was doing something for [NBA] All-Star [Weekend]. I was like, 'Yo, I'mma get you this record, see if you like it.' He sent it right back. I went with it. Just to warm up the streets, let them know I'm coming."
Plies said of being on this cut with his fellow Southern street artist to MTV News: "For me, bruh, to have an opportunity to create the situation I created with my brother and to have an artist from a record-selling standpoint and accomplish what the Snowman accomplished and to reach out to us and allow us to know there was a situation he wanted us to be a part of, it speaks a lot to what we gained and built in this business. It speaks a lot of him as a person. A lot of times in this game, a lot of cats can respect you and be scared to show you they respect you. I take my hat to him for it. It was my job to deliver him what I call an 'antique' verse and watch the record respond out of the gate like it is in the clubs and in the streets. I think we got a hell of a situation."