In 2008 guitarist Fred Mascherino left Taking Back Sunday in order to focus on his then upcoming solo album with The Color Fred. After his departure, Mascherino claimed in an interview with Long Island's Newsday that Taking Back Sunday was "more about cooking food than making music." Mascherino's departure and the comments he made afterwards were the inspiration for this song.
Mcclaine from Athens, GaI think this song is about Fred. 'the nicest man' i guess they're talkin bout fred and how they let him down and they actually looked up to him. 'the receeding pride of his twenties was capatal M-E' means that they think he left because they were mean to him or lowered his self esteem or something and they're admitting that its all their fault. thats how i see it.