Queensrÿche singer Todd La Torre explained the song's meaning to Billboard magazine: "'Guardian' touches on the empowering qualities of strength in numbers, and how people can rise up to create real change," he said. "Movements are evident across the globe in varying degrees, ranging from ideological perspectives and how they relate to cultures, socioeconomic differences and its effects, human rights, etc."
"It is an anthem that supports people standing up for rights and values that may be infringed upon on the micro and macro level," La Torre continued. "It's a single thread that surrounds a multifaceted topic of being human, human relationships relating to others and the world that surrounds us. Good, bad or indifferent, change is possible, but is only as strong as its relativity to perception, which perhaps is the very foundation and basis for the initiation of change."