The bluesy song refers to the Duquesne (pronounced doo-kayne) train service that used to run between New York Penn and Pittsburgh Penn Stations, which was named after the 18th century Fort Duquesne in the latter city. That route is now served by the daily Amtrack Pennsylvanian service. The lyrics show Dylan's distaste at times a changing'
. "Listen to that Duquesne whistle blowing," he demands. "Blowing like it's gonna sweep my world away."